Dr. Ayres specializes in all forms of corneal transplantation and was the first person at Wills Eye Hospital to perform Descemet membrane endothelial keratoplasty. He also has an interest in complex anterior segment repair. He is an active participant in clinical research and resident and fellow education. In his first year as an attending, he became the youngest recipient of the Golden Apple Award at Wills Eye. He lectures nationally and internationally at numerous academic conferences.